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1 and zhuhai rabeprazole sodium pharmacological effects:

Rabeprazole sodium azole belongs to inhibit the secretion of drugs, is a substitute of benzene and imidazole, no anticholinergic and H2 histamine resistance characteristics, but can be attached to the cell surface in the wall of the stomach by inhibiting the H + / K + atpase to suppress the secretion of stomach acid. The enzyme system is regarded as acid proton pump, so the rabeprazole azole sodium as proton pump inhibitors block the generation of stomach acid in the stomach, this effect is dose of correlation. Animal experiments confirmed that the zhuhai rabeprazole sodium azole shortly after medication from the eduction in plasma and gastric mucosa. Inhibition of gastric acid secretion characteristic: in oral rabeprazole sodium azole play in one hour work in 20 mg, the blood drug concentration in 2 ~ 4 hours of peak, in the first time with rabeprazole azole sodium 23 hours after inhibits gastric acid amount and amount of hydrochloric acid in gastric juice produced by food stimulation, inhibition rate were 69% and 82% respectively, and the time up to 48 hours, the action time significantly longer than the half-life of pharmacokinetic (about 1 hour). Mechanism for the inhibition of H + / K + atpase. Zhuhai rabeprazole sodium azole effect on inhibition of gastric acid secretion increases with dose can slightly increase, but three days later can reach stable level. Even after the drug withdrawal, this also can maintain stable level 2 ~ 3 days.

2 and zhuhai rabeprazole sodium toxicology studies:

1) to 5 mg/kg dose of rat oral toxicity test for 2 years, found in female rats stomach carcinoid.

2) experiments on animals (rat oral more than 25 mg/kg), found that blood thyroxine in the thyroid weight and increases, so should pay attention to when taking thyroid function. Influence on serum gastric secrete element: clinical trials, patients received zhuhai rabeprazole azole sodium 10 or 20 mg mg, 1 time/day, treatment for 24 months of treatment. Stomach secrete hormone level in serum increased 2 ~ 8 weeks. Usually within one to two weeks after discontinuation of serum gastric secrete element values can be restored to the level before treatment.

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