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Incidence of peptic ulcer disease is a kind of common disease, frequently-occurring disease, accounts for about 10% of the population. The digestive tract ulcer medications are proton pump inhibitors (omeprazole micro pill, etc.), H2 receptor antagonist (ranitidine, etc.), gastric mucous ulcer (bi), antacids (aluminum hydroxide). At present domestic the most widely used proton pump inhibitors omeprazole micro pill, sales occupy the first treatment for gastrointestinal ulcers. Prilosec (Omeprazole, Omep) is for the first time in 1979 Sweden Hassle company synthesis benzene and imidazole derivatives, compared with the existing of peptic ulcer drugs, has obvious advantages.

Omeprazole micro pill is suitable for gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis and - ai syndrome (stomach secrete melanoma). Omeprazole micro pill for fat-soluble weak alkaline, easy concentration in acid environment, thus can spread in the stomach after oral mucous membrane of parietal cells secrete small tube, and under the environment of high acid into the active form of sulfonamide, then through disulfide bond with the parietal cells secrete membrane of H +, K + atpase (also known as proton pump) of thiol is a combination of irreversibility, generate the sulfonamide compounds with proton pump, thus inhibiting the enzyme activity, blocking the final stages of gastric acid secretion, so omeprazole micro pill for various reasons caused by inhibition of gastric acid secretion has a strong and long lasting.

After oral omeprazole micro pill, the small intestinal absorption, work in 1 hour, 0.5 ~ 3.5 hours blood drug concentration reaches peak, effect persists for more than 24 hours can be distributed to the liver, kidney, stomach, duodenum, thyroid and other tissues, and easy through the placenta. Usually a single dose bioavailability by about 35%, multi-dose bioavailability increased to about 60%, plasma protein combined rate of 95% ~ 95%, the plasma half-life of 0.5 ~ 1 hour, chronic liver disease patients for three hours. Omeprazole micro pill hepatic somatic cell pigment particles of P450 enzyme systems in the body metabolism, about 80% of the urinary excretion of metabolites, after the rest by bile secretion from feces excretion.

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