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Single oral rabeprazole sodium azole 20 mg, maximum plasma concentration (Cmax) 0.406 mg per liter, the peak time (tmax) for 3.1 h, plasma half failure (t1/2) is 1.02 h, clearance (CL) for every 0.504 L/kg; Daily oral rabeprazole sodium azole 40 mg 7 days in a row, Cmax is 0.418 mg/L, tmax is 3.8 h. T1/2 to 1.49 h, CL 0.648 L/kg/day. The Cmax is dose dependency, but tmax, t1/2 and CL is not dependent on the dose. Rabeprazole sodium azole main hepatic metabolism and plasma protein combined rate of 94.8% ~ 94.8%. After a meal, although Cmax is no change, tmax was significantly delayed (1.7 h). Amount of urine excreted within 48 h with rabeprazole azole sulfur ether carboxylic acid and glucuronic acid compound calculation accounted for 34% of dosage.

Drug interactions

1. Because the rabeprazole azole sodium pH value, can increase the stomach with digoxin share, can promote the absorption of digoxin and result in higher concentration in its blood, so the party should be monitoring the concentration of digoxin.

2. According to the report, rabeprazole azole sodium and contain hydroxide of aluminum, hydroxide, magnesium antacids, at the same time again after taking antacids 1 h or unavailable, rabeprazole sodium azole average plasma drug concentration and the area under the curve fell by 8% and 8% respectively.

3. Ketoconazole does not affect the rabeprazole sodium azole metabolism, but rabeprazole reduces ketone health zun azole sodium Cmax it when applied ketone health zun, should be discontinued rabeprazole azole sodium.

4. The study of healthy volunteers, have been found rabeprazole sodium and diazepam, theophylline, warfarin, the interaction between phenytoin sodium.

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